Intervertebral Disc Biology: Genetic Basis of Disc Degeneration
نویسندگان
چکیده
منابع مشابه
incidence of microscopic lumbar intervertebral disc calcification and its correlation to endplate degeneration type and disc histopathologic angiogensis
چکیده ندارد.
15 صفحه اولDegeneration of the intervertebral disc
The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry, but morphologically it is clearly different. It shows degenerative and ageing changes earlier than does any other connective tissue in the body. It is believed to be important clinically because there is an association of disc degeneration with back pain. Current treatments are predomina...
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Degenerative disc disease is a serious health problem worldwide, whose etiological basis – mechanical stimulus, biochemical changes, or natural aging – is poorly understood. While the disc’s known function is that of dynamic shock absorber, its dynamic response has not been fully characterized throughout the disc health spectrum (from healthy to degenerate). Therefore, this study aimed to corre...
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Intervertebral disc degeneration is a major cause of low back pain. Despite its long history and large socio-economical impact in western societies, the initiation and progress of disc degeneration is not well understood and a generic disease model is lacking. In literature, mechanics and biology have both been implicated as the predominant inductive cause; here we argue that they are interconn...
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Intervertebral disc degeneration is associated with back pain and disc herniation. This study established a modified protocol for intervertebral disc (IVD) decellularization and prepared its extracellular matrix (ECM). By culturing mesenchymal stem cells (MSCs)(3, 7, 14 and 21 days) and human degenerative IVD cells (7 days) in the ECM, implanting it subcutaneously in rabbit and injecting ECM mi...
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ژورنال
عنوان ژورنال: Current Molecular Biology Reports
سال: 2018
ISSN: 2198-6428
DOI: 10.1007/s40610-018-0101-2